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71.
F.W. Gibbs M.Sc. Ph.D. 《Annals of science》2013,70(2):122-151
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Arthur Hughes M.A. Ph.D. Sc.D. 《Annals of science》2013,70(3):233-264
This note discusses lecture plates at the Hugo de Vries Laboratorium that may be relevant to Hugo de Vries's claim to have independently discovered Mendel's law of segregation. Dating when the plates were made is problematic. 相似文献
74.
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76.
S. Leysen L. Vanderkelen S. D. Weeks C. W. Michiels S. V. Strelkov 《Cellular and molecular life sciences : CMLS》2013,70(6):1113-1122
Gram-negative bacteria can produce specific proteinaceous inhibitors to defend themselves against the lytic action of host lysozymes. So far, four different lysozyme inhibitor families have been identified. Here, we report the crystal structure of the Escherichia coli periplasmic lysozyme inhibitor of g-type lysozyme (PliG-Ec) in complex with Atlantic salmon g-type lysozyme (SalG) at a resolution of 0.95 Å, which is exceptionally high for a complex of two proteins. The structure reveals for the first time the mechanism of g-type lysozyme inhibition by the PliG family. The latter contains two specific conserved regions that are essential for its inhibitory activity. The inhibitory complex formation is based on a double ‘key-lock’ mechanism. The first key-lock element is formed by the insertion of two conserved PliG regions into the active site of the lysozyme. The second element is defined by a distinct pocket of PliG accommodating a lysozyme loop. Computational analysis indicates that this pocket represents a suitable site for small molecule binding, which opens an avenue for the development of novel antibacterial agents that suppress the inhibitory activity of PliG. 相似文献
77.
G. E. Callander R. A. D. Bathgate 《Cellular and molecular life sciences : CMLS》2010,67(14):2327-2341
Since its discovery in the 1920s, relaxin has enjoyed a reputation as a peptide hormone of pregnancy. However, relaxin and
other relaxin family peptides are now associated with numerous non-reproductive physiologies and disease states. The new millennium
bought with it the sequence of the human genome and subsequently new directions for relaxin research. In 2002, the ancestral
relaxin gene RLN3 was identified from genome databases. The relaxin-3 peptide is highly expressed in a small region of the brain and in species
from teleost to primates and has both conserved sequence and sites of expression. Combined with the discovery of the relaxin
family peptide receptors, interest in the role of the relaxin family peptides in the central nervous system has been reignited.
This review explores the relaxin family peptides that are expressed in or act upon the brain, the receptors that mediate their
actions, and what is currently known of their functions. 相似文献
78.
Zinc-indium-tin oxide (ZITO) films were grown by pulsed-laser deposition.Three different material compositions were investigated:ZITO-30,ZITO-50 and ZITO-70 in which 30%,50% and 70%,respectively,of the... 相似文献
79.
Lekelia D. Jenkins 《Studies in history and philosophy of science》2010,41(1):75-85
This paper explores the evolution of a trading zone by organizing the case study of turtle excluder devices within the model proposed by Collins et al. (2007). The case study offers evidence that trading zones do evolve and that the concepts of enforced and fractionated trading zones hold practical utility for describing and defining the complexities of actual exchanges. In this case a trading zone evolved from enforced to fractionated and ultimately diverged into two trading zones. For each step of the evolution I describe the forces that drove these transitions. Finally, I present an adapted trading zone model that is conceptually a better fit for the turtle excluder device case study. 相似文献
80.
Species diversity, niche metrics, cover, frequency, and soil relationships were studied on high mountain meadows on adjacent cattle and sheep allotments in Strawberry Valley, Wasatch County, Utah. The cattle allotment vegetation was predominantly Mountain bluebell (Mertensia ciliata) , and the sheep allotment vegetation was predominantly Smallwing sedge (Carex microptera) . Other species of importance on both areas included Letterman needlegrass (Stipa lettermanii) , Mountain bromegrass (Bromus carinatus) , and Yarrow (Achillea millefolium) . Tall forbs were most abundant on the cattle allotment, and low forbs, perennial grasses, and sedges were most abundant on the sheep allotment. Vegetation composition on the two allotments was significantly different. 相似文献